A recent study led by Dr. Tamara Garrido from the Carlos Simon Foundation and INCLIVA, recently published in Nature Medicine, sheds light on the molecular mechanisms behind preeclampsia—a severe pregnancy complication affecting 8% of pregnancies worldwide.
The research focuses on decidualization, a process that prepares the uterine lining (endometrium) for embryo implantation and healthy pregnancy development. In women with preeclampsia, this process is disrupted, leading to serious risks for both mother and baby.
Using advanced technologies, including single-cell sequencing and spatial biology, the research team developed an “interactive map” of the endometrium. This innovative tool reveals critical failures in cellular interactions within the uterine lining of women with preeclampsia. Beyond its significance for preeclampsia, these findings also hold potential for understanding and treating other gynecological conditions like endometriosis.
“This study opens the door to personalized treatments and improved diagnostics for preeclampsia and other uterine conditions,” said Dr. Carlos Simon, president of the Carlos Simon Foundation.
The study represents a collaborative effort with leading national and international institutions and was supported by public and private funding, including the European Human Uterus Cell Atlas (HUTER) project and Spain’s Instituto de Salud Carlos III.
Read the full article in Nature Medicine here