Description
Preeclampsia is a major obstetric complication affecting 8% of first-time pregnancies with grave consequences for both mother and child. Despite years of investigation, a complete understanding of pathogenesis remains elusive, which compounds the difficulties in identifying predictive biomarkers and developing targeted therapeutic strategies. The unsolved question is why shallow trophoblast invasion occurs during placentation; our group turned its attention to the maternal decidua.
We focus on deciphering the origin and causes of pregnancy complications, such as preeclampsia.
We have provided evidence of defective decidualization in the endometrium of women with preeclampsia, which is detected at delivery and lingers for years afterward.
Our primary challenge is elucidating the molecular mechanisms underlying this defect at single-cell resolution, which will help develop strategies for early detection and novel therapies focused on preventing and treating preeclampsia.
Description
Preeclampsia is a major obstetric complication affecting 8% of first-time pregnancies with grave consequences for both mother and child. Despite years of investigation, a complete understanding of pathogenesis remains elusive, which compounds the difficulties in identifying predictive biomarkers and developing targeted therapeutic strategies. The unsolved question is why shallow trophoblast invasion occurs during placentation; our group turned its attention to the maternal decidua.
We focus on deciphering the origin and causes of pregnancy complications, such as preeclampsia.
We have provided evidence of defective decidualization in the endometrium of women with preeclampsia, which is detected at delivery and lingers for years afterward.
Our primary challenge is elucidating the molecular mechanisms underlying this defect at single-cell resolution, which will help develop strategies for early detection and novel therapies focused on preventing and treating preeclampsia.
Team members
Dr. Garrido is a molecular biologist focusing on endometrial physiology, specifically decidualization, the first steps of embryo invasion and placentation (PMID: 21190976). She graduated in Biological Sciences (2007) and received her Ph.D. qualification in molecular biology (2012) from the University of Valencia (Spain).
Her post-doctoral training (2.5 years) was developed in the laboratory of Susan Fisher at UCSF (USA) before forming part of the INCLIVA Biomedical Research Institute in 2013. Her post-doctoral investigations allowed her to gain expertise in uterine contributions to pregnancy complications, mainly focusing on preeclampsia (PMID: 28923940; PMID: 34709177).
She has published more than 17 high-impact peer-reviewed publications in prestigious journals such as PNAS, eLife, Development, and the American Journal of Obstetrics & Gynecology (AJOG) and has participated in over 20 international conferences. She supervises medical students in their final projects, directs Ph.D. theses, and participates in national and international projects.
She is currently the Senior principal investigator in the R&D department at Carlos Simon Foundation and the scientific manager at iPremom Pregnancy HealthCare Diagnostics S.L. Her primary research focuses on uterine contributions to preeclampsia and main pregnancy complications for their early detection and the development of novel therapies.
ResearcherID: B-6551-2017
Teresa Cordero, Ph.D.
Postdoctoral Researcher
Nerea Castillo, Ph.D.
Postdoctoral Researcher
Maria Cristina Carbajo, Ph.D.
Postdoctoral Researcher
Irene Muñoz
Predoctoral Researcher
Carla Montagud
Predoctoral Researcher
Sheila Ortega
Laboratory Technician
Main Publications
Decidualization resistance in the origin of preeclampsia
Garrido-Gomez T, Castillo-Marco N, Cordero T, Simon C.
Am J Obstet Gynecol. 2022;26(2S):S886-S894 PMID: 33007270.
Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia
Garrido-Gomez T*, Castillo-Marco N*, Clemente-Ciscar M*, Cordero T, Muñoz-Blat I, Amadoz A, Jimenez-Almazan J, Monfort-Ortiz R, Climent R, Perales-Marin A, Simon C.
Elife. 2021 Oct 28;10:e70753. doi: 10.7554/eLife.70753. PMID: 34709177; PMCID: PMC8553341
Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2
Garrido-Gomez T, Quiñonero A, Dominguez F, Rubert L, Perales A, Hajjar KA, Simon C.
Am J Obstet Gynecol. 2020;222(4):376.e1-376.e17. Epub 2019. PMID:31738896.
Defective decidualization during and after severe pre-eclampsia reveals a possible maternal contribution to the etiology
Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simon C.
Proc Natl Acad Sci USA 2017 3;114(40): E8468-E8477.
Modelling human endometrial decidualization from the interaction between proteome and secretome
Garrido-Gomez T, Dominguez F, Lopez JA, Camafeita E, Quiñonero A, Martinez-Conejero JA, Pellicer A, Conesa A, Simon C.
J Clin Endocrinol Metab 2011; 96(3):706-16. doi: 10.1210/jc.2010-1825