Description
Our research group described the existence of the endometrial microbiome and its clinical implications in reproductive outcomes.
Our results suggest that pathogenic deviations of bacteria of the Lactobacillus genus in the endometrium could play a role in infertility.
We aim to apply molecular microbiology techniques to investigate the role of the endometrial microbiome in infertility and obstetric complications such as implantation failure, recurrent miscarriage, and preterm birth.
Description
Our research group described the existence of the endometrial microbiome and its clinical implications in reproductive outcomes.
Our results suggest that pathogenic deviations of bacteria of the Lactobacillus genus in the endometrium could play a role in infertility.
We aim to apply molecular microbiology techniques to investigate the role of the endometrial microbiome in infertility and obstetric complications such as implantation failure, recurrent miscarriage, and preterm birth.
Research line image credits
Reprinted from American Journal of Obstetrics and Gynecology, 222(4). Moreno I, Garcia-Grau I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella F, Romero R, Simón C. The first glimpse of the endometrial microbiota in early pregnancy, 296-305, Copyright (2020), with permission from Elsevier
Team members
Inmaculada Moreno is a Senior Principal Investigator at the Carlos Simon Foundation for Research in Women’s Health, where she develops basic and translational research projects regarding the impact of the microbiome in human reproduction.
Her main scientific interest is understanding how microorganisms impact embryo implantation, pregnancy success, and women’s health in general.
She demonstrated the existence of the endometrial microbiota (PMID: 27717732) and reported an association between the microbiome and reproductive outcomes in infertile patients (PMID: 34980280). Furthermore, she studied the functional impact of bacteria present in the endometrium in reproductive failure (PMID: 31653041) and, for the first time, during early successful pregnancy (PMID: 32057732). Her research also focuses on improving diagnostic methods for chronic endometritis, a subclinical infection of the endometrium with adverse effects on fertility (PMID: 29477653), and searching for potential probiotics for endometrial health (PMID: 31058101).
Dr. Moreno has more than 15 years of professional experience in molecular microbiology and biochemistry. From 2015 to 2018, she collaborated with the Reproductive and Stem Cell Biology laboratory at Stanford University School of Medicine as a Visiting Scholar. She has been productive in basic and clinical research with over 40 published papers in peer-reviewed journals with an accumulated impact factor of 279.94. Her papers have been cited 1,279 times with an average of 30.45 citations/paper, and she has an H-Index of 21. She has published 5 invited book chapters, including the Encyclopedia of Reproduction, and has participated in over 100 international conferences.
ResearcherID: D-3955-2018
Maria Cristina Carbajo, Ph.D.
Postdoctoral Researcher
Bruno Toson
Predoctoral Researcher
Maria del Carmen Graciano
Predoctoral Researcher
Marta Gonzalez
Research Specialist
Main Publications
Endometrial microbiota composition is associated with reproductive outcome in infertile patients
Moreno I, Garcia-Grau I, Perez-Villaroya D, et al.
Microbiome. 2022. 10-1. ISSN 2049-2618.
The first glimpse of the endometrial microbiota in early pregnancy
Moreno I, Garcia-Grau I, Bau D, Perez-Villaroya D, Gonzalez-Monfort M, Vilella F, Romero R, Simon C.
American Journal of Obstetrics and Gynecology. 2020. 222, pp.296-305. ISSN 0002-9378.
Taxonomical and Functional Assessment of the Endometrial Microbiota in A Context of Recurrent Reproductive Failure: A Case Report
Garcia-Grau I, Perez-Villaroya D, Bau D, Gonzalez-Monfort M, Vilella F, Moreno I, Simon C.
Pathogens. 2019. pp.doi: 10.3390/pathogens8040205. ISSN 2076-0817.
The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I, Cicinelli E, Garcia-Grau I, et al.
American Journal of Obstetrics and Gynecology. 2018. Elsevier. 33-4, pp.745-756. ISSN 0002-9378.
Evidence that the endometrial microbiota has an effect on implantation success or failure
Moreno I, M Codoñer F, Vilella F; et al.
American Journal of Obstetrics and Gynecology. 2016. Elsevier. 215-6, pp.684-703. ISSN 0002-9378.