The Carlos Simon Foundation participates in the FUSENDO project, a research initiative focused on studying the role of the microbiome in ovarian endometriosis. The project, identified as PI24/00722, is led by Dr. Inmaculada Moreno and funded by the Carlos III Health Institute through the Health Research Projects call.
Endometriosis is a chronic inflammatory disease characterized by the presence of tissue similar to the endometrium outside the uterine cavity. It affects millions of women worldwide and can cause severe pelvic pain, infertility, and a significant impact on quality of life. Its diagnosis also remains complex and is often delayed for several years after the first symptoms appear.
FUSENDO is based on a key scientific question: can microbiome alterations contribute to the origin, maintenance, or progression of endometriosis? Recent studies have described differences in the endometrial and intestinal microbiota of women with endometriosis, but it is still not fully understood how these microbial communities may interact with tissue cells and participate in disease mechanisms.
The project aims to analyze microbiome-host interactions by integrating clinical data, microbiome profiles, and advanced omics technologies. This approach will allow a more precise study of the relationship between microorganisms present in the reproductive and intestinal tracts, their derived products, and the response of endometrial tissue.